Malaria is, for the most part, under control in South Africa.
The risk of being infected with malaria is minimal when taking preventative medication. Malaria tablets are only needed when travelling to one of the above-mentioned areas, and not when travelling to Cape Town or along the Garden Route. A good insect repellent (particularly in the evening), long-sleeved shirts, and mosquito coils/nets are advisable precautions. The best tip is to get advice from your doctor. In general you will need the same precautions and vaccinations in South Africa as you would need in your home country.